Hypersensitivity to Transfused Blood

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Study of Transfused Blood

Evidence is presented to show that there is no hemolytic toxin producing the anemia in pernicious anemia. Partial evidence is presented to show that the periods of active blood destruction which are seen as the exception in pernicious anemia cases during a series of transfusions are due to the activity of the blood-destroying organs of the body rather than to the intrinsic weakness of the perni...

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Biologic effects of leukocytes present in transfused cellular blood products.

A considerable literature has accumulated over the past decade indicating that leukocytes present in allogeneic cellular blood components, intended for transfusion, are associated with adverse effects to the recipient. These include the development of febrile transfusion reactions, graft-versus-host disease, alloimmunization to leukocyte antigens, and the immunomodulatory effects that might inf...

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Age of transfused blood in critically ill adults.

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Free haemoglobin in 'old' transfused blood - baddy or bystander?

In the previous issue of Critical Care, Vermeulen Windsant and colleagues demonstrate that transfusion of packed red cells is associated with a transient increase in plasma free haemoglobin and scavenging of nitric oxide in vitro. They also demonstrate that older units of blood have more free haemoglobin in their supernatants. Whether the administration of older stored blood results in adverse ...

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ژورنال

عنوان ژورنال: BMJ

سال: 1945

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.4411.83